Where is c-Met expressed?

Where is c-Met expressed?

The protein product of this gene is the c-MET tyrosine kinase. This cell surface receptor is expressed in epithelial cells of many organs, including the liver, pancreas, prostate, kidney, muscle and bone marrow, during both embryogenesis and adulthood [Comoglio et al. 2008].

What is c-Met in lung cancer?

The c-Met receptor is a tyrosine kinase receptor for hepatocyte growth factor (HGF), also known as scatter factor (SF). HGF is a heparin-binding protein that shares structural domains with enzymes of the blood clotting cascade.

Is MET and c-Met same?

c-Met, also called tyrosine-protein kinase Met or hepatocyte growth factor receptor (HGFR), is a protein that in humans is encoded by the MET gene. The protein possesses tyrosine kinase activity.

What type of receptor is c-Met?

Background. c-Met (mesenchymal-epithelial transition factor), which belongs to the MET family, along with RON, is a type of receptor tyrosine kinase that is expressed on the surfaces of various epithelial cells; its ligand is HGF/SF(ligand hepatocyte growth factor/scatter factor) [1, 2].

What does the MET gene code for?

MET (MET Proto-Oncogene, Receptor Tyrosine Kinase) is a Protein Coding gene. Diseases associated with MET include Renal Cell Carcinoma, Papillary, 1 and Deafness, Autosomal Recessive 97. Among its related pathways are NF-kappaB Pathway and Cytokine Signaling in Immune system.

What does the ALK gene do?

The ALK gene provides instructions for making a protein called ALK receptor tyrosine kinase, which is part of a family of proteins called receptor tyrosine kinases (RTKs). Receptor tyrosine kinases transmit signals from the cell surface into the cell through a process called signal transduction.

What does C-met stand for?

Biomarker Abbreviation: c-MET. Definition: also known as mesenchymal epithelial transition factor (MET) or hepatocyte growth factor receptor (HGFR) – a proto-oncogene active in cell signaling, c-MET promotes cancer cell growth and multiplication.

What is C-MET overexpression?

C-MET overexpression as a resistance biomarker to epidermal growth factor receptor tyrosine kinase inhibitors in EGFR-mutant non-small cell lung cancer.

What is c-Met test is for?

c-Met, a cell surface receptor tyrosine kinase, regulates cellular proliferation, migration, and differentiation during development. Increased expression of c-Met has been shown to correlate with poor prognosis in nonsmall cell carcinomas of the lung.

What does MET receptor stand for?

MET (MET Proto-Oncogene, Receptor Tyrosine Kinase) is a Protein Coding gene. Diseases associated with MET include Renal Cell Carcinoma, Papillary, 1 and Deafness, Autosomal Recessive 97. Among its related pathways are Apoptotic Pathways in Synovial Fibroblasts and CREB Pathway.

Is MET a EGFR?

The basic mechanism by which MET amplification causes EGFR-TKI resistance is associated with the activation of EGFR-independent phosphorylation of ErbB3 and downstream activation of the PI3K/AKT pathway, providing a bypass signaling pathway even in the presence of an EGFR-TKI (Fig. 3) [5].