How phenytoin be synthesized from benzil explain?
Principle: Base catalyzed reaction between benzyl and urea is used for synthesis of phenytoin. The reaction is proceeding via intramolecular cyclization to form an intermediate heterocylic pinacol, which on acidification yield hydantoin (phenytoin) as a result of 1,2-diphenyl shift in pinacol rearrangement reaction.
How is phenytoin synthesized?
Phenytoin (5,5′-dipenylimidazolidine-2,4-dione) is the prime example of anticonvulsant agent. According to reported procedure, it is synthesized by condensation of benzil and urea in presence of base (30% w/v NaOH) using ethanol as solvent which itself acts as CNS stimulant.
What is the melting point of phenytoin?
Phenytoin (PHT; 5,5-diphenylhydantoin) is a weak acid with pKa of 8.3 (1). The compound is a crystalline substance with a molecular weight of 252.3 and a melting point of 295-298 C.
Which reagent is used as the solvent in the synthesis of phenytoin?
Phenytoin is synthesized by application of principle of green chemistry with high purity profile as well as having safety by omitting the use of ethanol. Water a green solvent is used instead of ethanol in synthesis of phenytoin .
What is benzil Benzilic acid rearrangement?
The benzilic acid rearrangement is formally the 1,2-rearrangement of 1,2-diketones to form α-hydroxy–carboxylic acids using a base. This reaction receives its name from the reaction of benzil with potassium hydroxide to form benzilic acid.
What is phenytoin made of?
Each Dilantin— 100 mg Extended Oral Capsule—contains 100 mg phenytoin sodium. Also contains lactose monohydrate, NF; confectioner’s sugar, NF; talc, USP; and magnesium stearate, NF. The capsule body contains titanium dioxide, USP and gelatin, NF.
What is phenytoin soluble?
Phenytoin is a white, odorless powder at room temperature (Ak- ron 2009). It is practically insoluble in water, but it is soluble in ace- tone, ethanol, and alkali hydroxides (IARC 1996).
What is the melting point of benzil?
202.6°F (94.8°C)Benzil / Melting point
How do you convert benzil to benzilic acid?
How is phenytoin synthesized from benzyl and urea?
Please try again later. Base catalyzed reaction between benzyl and urea is used for synthesis of phenytoin. The reaction is proceeding via intramolecular cyclization to form an intermediate heterocylic pinacol, which on acidification yield hydantoin (phenytoin) as a result of 1,2-diphenyl shift in pinacol rearrangement reaction.1
What is the structural similarity between phenytoin and benzil?
Due to the small changes that happened in the spectrum of phenytoin when compared with that of Benzil, we can say that the structural similarity between phenytoin and Benzil is not much. In phenytoin, in addition to two Benzene ring, the formation of a five member ring containing two C=O and the two N-H groups occurs. 20.
What is the mechanism of action of phenytoin?
suppressant. The first action of Phenytoin is decrease the effect of seizure on motor cortex. Epilepsy caused by the rapid flow of sodium ions from neurons. It decreases the flow of sodium
What is the difference between phenytoin and Alpha benzilmonoxime?
Phenytoin was prepared by the reaction of benzil with urea in the presence of sodiumhydroxide. Alpha benzilmonoxime was prepared by the reaction of benzil with hydroxylamine hydrochloride in the presence of sodiumhydroxide and ethanol.