What does c-Src do?
c-Src phosphorylates specific tyrosine residues in other tyrosine kinases. It plays a role in the regulation of embryonic development and cell growth. An elevated level of activity of c-Src is suggested to be linked to cancer progression by promoting other signals.
How do Src family tyrosine kinase inhibitors work?
On activation, Src tyrosine kinase enzymes can phosphorylate various proteins like mitogen-activated protein kinase (MAPK), p38, and extracellular signal-regulated kinase (ERK). MAPKs regulate inflammation, cell development, cell differentiation, and cell senescence.
What type of kinase is Src?
non-receptor tyrosine kinases
Src family kinases (SFKs) are membrane-associated, non-receptor tyrosine kinases that act as important signaling intermediaries regulating a variety of outputs, such as cell proliferation, differentiation, apoptosis, migration, and metabolism.
What is Src signaling pathway?
Src transmits signals promoting cell survival and mitogenesis and, in addition, exerts a profound effect on the reorganization of the cytoskeleton and the adhesion systems that underpin cell migration and invasion.
How is SRC regulated?
Src family nonreceptor tyrosine kinases are present in essentially all metazoan cells, where their regulated activation by diverse growth factor, cytokine, adhesion, and antigen receptors is critical for generating an appropriate cellular response to external stimuli (Brown and Cooper, 1996; Thomas and Brugge, 1997).
How are Src family kinases activated?
Activation. Src kinases are activated through a variety of ligands binding to the SH2 and SH3 domains. They can also be activated through the SH3 domain being displaced while SH2 remains engaged with the C-terminal tail. Src can be activated by receptor tyrosine kinases such as EGFR and HGF receptors.
How is Src activated?
Src can be activated by several types of cell surface or cytoplasmic receptor. Shown here is, from left to right, a receptor tyrosine kinase such as the platelet-derived growth factor receptor; a G-protein-coupled receptor such as the β-adrenergic receptor; and an integrin bound to extracellular matrix.
What is the function of Src kinase?
Src Family Kinase. Src family kinases (SFKs) are the other group of nonreceptor tyrosine kinases involved in the regulation of various signaling pathways that promotes cell survival and motility.
How does src signaling contribute to cancer progression?
How Src signaling affects the formation of focal adhesions and interplay with the extracellular matrix and how changes in the signals transduced by this pathway contribute to cancer cell progression are also described.
What is the function of SRC in the CNS?
In the CNS, Src and other SFKs are widely expressed and are abundant in neurons. Src has been implicated in proliferation and differentiation during the development of the CNS. However, Src is also highly expressed in fully differentiated neurons in the developed CNS, implying additional functions.
Is p120-catenin an Src substrate or substrate?
Among the molecules that have been implicated in this regulatory pathway is p120-catenin, a protein originally identified as an Src substrate in v-Src transformed cells.