What are nitrogen containing heterocyclic compounds?
Some of the nitrogen-containing heterocyclic anti-cancer drugs are Axitinib, Bosutinib, Cediranib, Dasatanib (Sprycel®), Erlotinib (Tarceva®), Gefitinib (Iressa®), Imatinib (Gleevec®), Lapatinib (Tykerb ®), Linifanib, Sorafenib (Nexavar®), Sunitinib (Sutent®), Tivozanib, etc.
Can heterocycles be aromatic?
Heterocycles – cyclic structures in which the ring atoms may include oxygen or nitrogen – can also be aromatic.
Which heterocyclic ring contain nitrogen?
Pyridine and pyrrole are both nitrogen heterocycles—their molecules contain nitrogen atoms along with carbon atoms in the rings. The molecules of many biological materials consist in part of pyridine and pyrrole rings, and such materials yield small amounts of pyridine and pyrrole upon strong heating.
What are fused heterocyclic compounds?
A compound that can be used as a donor material in organic photovoltaic devices comprising a non-activated porphyrin fused with one or more non-activated polycyclic aromatic rings or one or more non-activated heterocyclic rings can be obtained by a thermal fusion process.
What are nitrogen heterocyclic compounds used for?
A vast number of nitrogen-containing heterocyclic compounds are known to exhibit a wide range of pharmacological activities including anticancer, anti-HIV, antimalaria, anti-tubercular, anti-microbial and diabetic activities [19,20,21,22,23,24,25].
Which of the following is five membered nitrogen containing heterocycles?
Major fractions of organic compounds isolated from nature are comprised of nitrogen heterocycles. Such five-membered nitrogen heterocycles with a pyrrolidine ring system include nicotine, tryptamine, and vinblastine and possess considerable biochemical, pharmaceutical, and agricultural importance.
Does nitrogen contribute to aromaticity?
Both of the nitrogens in pyrimidine have lone pair electrons contained in a sp2 orbitals and are not involved in the aromatic system.
How do you name fused heterocyclic compounds?
3.1 – “Ortho-fused” and “ortho- and peri-fused” ring compounds containing hetero atoms are named according to the fusion principle described in Rule A-21 for hydrocarbons. The components are named according to Rules A-21, B-1 and B-2.
What is fused heterocyclic ring?
A general approach to the synthesis of (6:5:6) fused heterocyclic ring systems involves intramolecular cyclization of two substituents attached to a five-membered ring of the fused (6:5) system.
Which of the following heterocycles is most aromatic?
Hence thiophene (B) is most aromatic in nature.
Which of the following is a heterocyclic aromatic compound?
The compounds pyridine, 1H-pyrrole and thiophene are heterocyclic aromatic compounds.