What is the drug of choice for GERD?

Table of Contents

Acid-suppressive agents have become the drugs of choice for GERD. Both proton pump inhibitors (PPIs) and histamine H2-receptor antagonists (H2-RA) are effective and can be safely used to treat GERD.

Which medication increases lower esophageal sphincter pressure?

Prokinetic agents, such as metoclopramide (Reglan), improve the motility of the esophagus and stomach and increase the lower esophageal sphincter (LES) pressure to help reduce reflux of gastric contents.

What blood pressure medications cause GERD?

Calcium channel blockers such as nifedipine (Procardia) and beta blockers such as propranolol (Inderal) can also cause heartburn. Speak to your doctor if you are experiencing problems.

What drugs relax the lower esophageal sphincter?

Several common medications have been shown to relax the lower oesophageal sphincter, including benzodiazepines, calcium channel blockers, nitrates, xanthines, and most significantly b2 agonists.

Do beta blockers relax the lower esophageal sphincter?

Nifedipine, a calcium-channel blocker, was shown to decrease lower esophageal sphincter pressure and increase esophageal acid exposure time, while atenolol, a β1 blocker, was shown to inhibit relaxation of the smooth muscle of the esophagus.

What medications make GERD worse?

Antibiotics, such as tetracycline and clindamycin.
Bisphosphonates taken orally, such as alendronate (Fosamax), ibandronate (Boniva) and risedronate (Actonel, Atelvia)
Iron supplements.
Quinidine.
Pain relievers, such as ibuprofen (Advil, Motrin IB, others) and aspirin.
Potassium supplements.

Can you take omeprazole with blood pressure medicine?

Adding omeprazole to long-term amlodipine therapy in patients with hypertension and ARD may lead to a significantly more pronounced antihypertensive effect in patients genotyped CYP2C19 IMs.

https://www.youtube.com/watch?v=-MduikwcAmE