What does an abnormal protein band 1 mean on electrophoresis?
Optimal Result: 0 – 0.01 g/dL. When an abnormal protein (band or peak) is detected, additional tests are done to identify the type of protein (immunotyping). Possible monoclonal protein (M-protein) present.
What is a beta 1 globulin?
LP31518-1 Beta 1 globulin. Beta globulins are a group of globular proteins in plasma that are more mobile in alkaline or electrically charged solutions than gamma globulins, but less mobile than alpha globulins.
What does a high beta 1 globulin mean?
Increased beta globulin proteins may indicate: A disorder in which the body has problems breaking down fats (for example, hyperlipoproteinemia, familial hypercholesterolemia) Estrogen therapy.
What does a protein electrophoresis test show?
What is this test? Protein electrophoresis is a test that measures specific proteins in the blood. The test separates proteins in the blood based on their electrical charge. The protein electrophoresis test is often used to find abnormal substances called M proteins.
What is beta in protein electrophoresis?
Beta1 is composed mostly of transferrin, and beta2 contains beta-lipoprotein. IgA, IgM, and sometimes IgG, along with complement proteins, also can be identified in the beta fraction.
What is alpha1 globulin?
α1 globulins. They comprise: α1-antiproteinase or α1-antitrypsin is a glycoprotein with a mass of 50 kDa and a total carbohydrate content of 12%. It is one of the main inhibitors of plasma serine proteases, protecting tissues (especially the lung) from the action of proteases released by polymorphonuclear granulocytes.
What does high beta protein mean?
Increased beta fraction Beta globulin level may be raised in severe iron deficiency when there are high levels of transferrin. It may be decreased in malnutrition and cirrhosis.
What does a high alpha 1 mean?
What does it mean if your Alpha-1-Globulin, Serum result is too high? Increased alpha-1 globulin proteins may be due to: Acute inflammatory disease. Chronic inflammatory disease (for example, rheumatoid arthritis, SLE) Cancer.
What do thicker bands mean in gel electrophoresis?
Thicker bands in gel electrophoresis mean there is more of that particular size molecule in the sample.
What is a protein electrophoresis test?
Protein electrophoresis tests give a healthcare practitioner a rough estimate of how much of each of the protein fractions is present and whether any abnormal proteins or protein patterns are present. Results are interpreted along with your signs and symptoms and medical history.
What is the role of electrophoresis in the workup of hypoproteinemia?
Protein electrophoresis can also be used to monitor response to treatment. In liver failure, extremely low plasma protein concentrations can occur in combination with a decreased A/G ratio. Gastrointestinal and renal diseases can also lead to severe hypoproteinemia.
What is the difference between beta 1 and beta 2 lipoprotein?
Beta 1 is composed mostly of transferrin, and beta 2 contains beta-lipoprotein. IgA, IgM, and sometimes IgG, along with complement proteins, also can be identified in the beta fraction.
Is protein electrophoresis a revolution in population genetics?
If protein electrophoresis represented a renaissance in population genetics, the advent of direct deoxyribonucleic acid (DNA) analyses represented a revolution and led to a new branch of population genetics referred to as molecular evolution (Graur and Li, 2000 ).