What does a high interleukin-2 mean?
The interleukin-2 receptor is a heterotrimeric transmembrane protein that is upregulated on activated T cells, and high sIL-2r levels are found in hemophagocytic syndromes, lymphoma, autoimmune lymphoproliferative syndrome, and other conditions associated with T-cell activation.
How much does interleukin-2 cost?
CHIRON/CETUS’ PROLEUKIN (IL-2) THERAPY WILL COST $6,000-$8,000 PER COURSE, based on the average use of 30-35 vials per therapeutic cycle for adults with metastatic renal cell carcinoma, Chiron said May 5 following FDA’s approval of human recombinant interleukin-2 (aldesleukin).
What is IL-2 a marker of?
Besides its potent T-cell growth factor activity, IL-2 induces proliferation of natural killer (NK) cells and augments their cytolytic activity as well as that of lymphokine-activated killer cells (Siegel et al., 1987), promotes antibody production and proliferation by B cells (Mingari et al., 1984), and is essential …
What is IL-2 chemo?
It is also known as interleukin 2 (IL-2) or by its brand name Proleukin. It is a treatment for kidney cancer that has spread to another part of the body (advanced kidney cancer). It is also used in clinical trials for other types of cancer.
What is interleukin used for?
One of a group of related proteins made by leukocytes (white blood cells) and other cells in the body. Interleukins regulate immune responses. Interleukins made in the laboratory are used as biological response modifiers to boost the immune system in cancer therapy.
What autoimmune diseases does high levels interleukin 2 receptor effect soluble serum?
Our experience regarding serum soluble interleukin-2 receptor (sIL-2R) measurement as a marker of lymphocyte activation consists of patients with autoimmune disease: 37 with systemic lupus erythematosus (SLE), 23 with autoimmune hepatitis (AIH), 74 with inflammatory bowel disease and six with Wegener’s granulomatosis ( …
What are the side effects of interleukin-2?
Side effects of IL-2 can include flu-like symptoms such as chills, fever, fatigue, and confusion. Some have nausea, vomiting, or diarrhea. Many people develop low blood pressure, which can be treated with other medicines.
Why is interleukin-2 important?
IL-2 has an immunoregulatory role; it promotes the growth and development of peripheral immune cells in the initiation of the (defensive) immune response, and keeps them alive as effector cells.
Is IL-2 pro or anti-inflammatory?
Both proinflammatory (IL2, IL6, IFNgamma, TNFalpha) and anti-inflammatory (IL4, IL10) cytokines were significantly increased in infected infants compared with non-infected infants.