Is GPR55 a orphan receptor?

Is GPR55 a orphan receptor?

In this study we show that the orphan G-protein-coupled receptor, GPR55, is a novel cannabinoid receptor with an ability to interact with and be modulated by endogenous, plant and synthetic cannabinoid ligands and to be a candidate for one of the non-CB1/CB2 receptors, described by others.

What is CB1R receptor?

The CB1R is a Gi/o protein-coupled receptor widely expressed in the brain, especially in areas such as cerebellum, cortex, substantia nigra, and limbic structures (Herkenham et al., 1990; Tsou et al., 1998).

What is the endocannabinoid system responsible for?

The endocannabinoid system regulates not only the central and peripheral mechanisms of food intake, but also lipids synthesis and turnover in the liver and adipose tissue as well as glucose metabolism in muscle cells.

What is the difference between CB1 and CB2 receptors?

CB1 receptors are located in the brain and throughout the body, while CB2 receptors are found mostly in the immune and gastrointestinal system; although CB2 receptors are also found in the brain, they are not expressed quite as densely as CB1 receptors.

What is rimonabant used for?

Rimonabant is an anorectic anti-obesity drug produced and marketed by Sanofi-Aventis. It is an inverse agonist for the cannabinoid receptor CB1. Its main avenue of effect is reduction in appetite. Rimonabant is the first selective CB1 receptor blocker to be approved for use anywhere in the world.

Does the human body naturally produce cannabinoids?

Endocannabinoids. Endocannabinoids, also called endogenous cannabinoids, are molecules made by your body. They’re similar to cannabinoids, but they’re produced by your body.

What does CB1 and CB2 receptors do?

Cannabinoid CB1 and CB2 receptors are 7-transmembrane G-protein coupled receptors (GPCRs). They play an important role in peripheral, spinal, and supraspinal nociception, including ascendant and descendent pain pathways (Hill et al., 2017).

Is CBD a CB2 agonist?

The ability of cannabidiol to behave as a CB2 receptor inverse agonist may contribute to its documented anti-inflammatory properties.

Is rimonabant a cannabinoid?

Rimonabant is a potent and selective cannabinoid CB1 receptor antagonist widely used in animal and clinical studies. Besides its antagonistic properties, numerous studies have shown that, at micromolar concentrations rimonabant behaves as an inverse agonist at CB1 receptors.